Peak shad runs occur in April. The shad live along the continental shelf and enter the bay and river to spawn. Shad are plankton feeders as are other herring that enter the river.

Bluefish inhabit Ramford Bay from May to October. They feed on silversides, young bunkers, shrimp, crabs and worms. Five pounds is the typical size for a four-year-old fish.

Weakfish inhabit the Bay from July to October. They feed on killifish, silversides, young herring, shrimp and small critters. Their name comes from the fact that after being hooked by fishermen their small, weak bones in their jaws break .

The American eel ranges from Newfoundland to the northern coast of South America. They inhabit all the waters in the interiors and along the coast from warm saline estuaries to cold, fresh water trout streams. The female eel lives almost exclusively in freshwater until it reaches sexual maturity. Males live in salt and brackish water. When it is time to mate,  they pass through Ramford Bay on their way to the Sargasso Sea. This cycle is reversed from that of the shad, striped bass and other fish that inhabit the sea and migrate to fresh water to spawn. Eels feed on worms, small crustaceans, and clams.

Bunkers are the most abundant fish in the bay; another name for the species is menhaden. Schools of bunkers appear in Ramford Bay in late May and early June and remain through the summer. In September they begin a southern migration. Bunkers feed on planktonic algae and small crustaceans they sift form the water with a straining apparatus. They spawn in the ocean, Ramford Bay, and other large saline bays along the coast.

Porgies are found in great abundance in the Bay from July to late October. They usually feed along the bottom feeding on worms small crustaceans and mollusks. They spawn from May to August and after October they migrate offshore and live over the continental shelf.

Fluke or summer flounder begin to enter Ramford Bay in April and are most abundant from July to August. They spawn on the continental shelf in the fall. In contrast Winter flounder spend their winter in Ramford Bay and spawn there in the spring.

Some other fish that  inhabit the bay, but in smaller numbers, include croakers, cunner, kingfish, mullet and tomcod.

The Bay at one time was an excellent habitat for shellfish. In the 1600ís oysters grew in two beds of substantial size. One was about a mile wide and  extended six miles in to the mouth of the river. A smaller bed known to the Renapi was located in a small harbor off the main Bay.

Oysters grow relatively slowly, about half an inch per year,  in salinities from five to ten parts per thousand. They grow about an inch per year in salinities of twelve to twenty parts per thousand. In salinities above fifteen ppt, the oyster's natural enemies are too prevalent for any beds to develop. The enemies include starfish, oyster drills, and crabs.

Ramford Bay is the southernmost bay in North America where the American lobster lives. South of the Bay lobsters live in the cooler offshore waters of the continental shelf.

Ramford Bay, conversely,  is the northernmost area where blue crabs occur. They are in great abundance during the winters and spend their summers in the tributaries of the Ramford River.

Horseshoe crabs migrate into the Bay in the spring. They spend most of their life lining on the continental shelf.